Friday, November 30, 2012

Would penicillin have been available for patients in 1930, if Fleming had produced his '29 paper - and then died ?

If only pneumonia had killed Alec, not John....
Imagine - if you will - that you're at a medical meeting - one of hundreds and hundreds that Alexander Fleming routinely attended between the Fall of 1928 and the Fall of 1942 and you happen to overhear Fleming regaling a small audience in the corridor about his 'wonderful' penicillin.


It is, he says (translated into today's medical terminology) a wide spectrum totally non-toxic anti-bacterial agent , the only one he as ever seen that doesn't harm the natural healing powers of the body's blood.

It is, Fleming says with great force , simply a great lab clearing agent for vaccine studies and potentially a useful antiseptic...

....And ? AND ?!  You wait for the other shoe to drop, somewhat impatiently : how is it as a systemic, for saving those dying from bacterial infections ?

Oh that, says Fleming indifferently , its useless for that.

And, he adds brutally honestly , as an antiseptic it is slow acting and is so unstable that it will only be useful if the chemists can synthesize it - but they haven't so far.

For fourteen years , I believe only one man stood between penicillin the potential life-saver for millions and penicillin the actual life saver for millions and that man was - unfortunately - Alexander Fleming.

The history of penicillin might have been quite different if only he and not his brother John had died of the pneumonia that Fleming's 1928 imperfect penicillin would have cured.

I can not believe that Fleming could offer such frequent public build-ups of his wonderful penicillin without someone in the audience venturing : well how do you rate its life-saving systemic qualities then ?

Fleming in his honest (but incorrect) way , would have had to say in public what he deliberately omitted from his published articles : 'as a systemic, I believe that penicillin is useless'.

This - more than anything someone else did or didn't do - dammed penicillin to wander useless in the desert for 15 years : its own discoverer damning it with the very faintest of praise ....

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Histories of WWII all start with the presumption that it was a war raged between humans and human ideologies, with Nature’s climate and geography as side issues easily surmounted.My blog, on the contrary will only accept that it was conflict between humans and their ideology that STARTED the war but that it was the barriers thrown up by Mother Nature (geography & climate) that turned it into a war that lasted between 6 to 15 years and expanded to thoroughly involve all the world’s oceans and continents. High Modernity may have started the war convinced that Nature had been conquered and was about to be soon replaced by human Synthetic Autarky and that only human Tiger tanks and human Typhoon planes were to be feared. But by the end, more and more people had lost their naive faith in Scientism and were beginning to accept that humanity was thoroughly entangled with both the Nature of plants, animals & microbes as well as the Nature of so called “lesser” humanity. By 1965, the world was definitely entering the Age of Entanglement. Billions still believed - at least in part -with the promises of High Modernity but intellectually & emotionally, it was no longer dominant...

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